Question 27

14 year old boy is brought to the Office with swelling of the right knee. The joint is extremely tender, and the boy walks with a limp. He has no fever or any history of trauma to the knee. Both his parents are healthy and fine. He gives history of his paternal uncle who had some eye surgery in childhood, but he passed away in his adolescent years. The X ray of the right knee shows spiculated pattern and bone lifting periosteum. Which of the following regulatory gene is responsible for the boy's knee lesion?

A) BRCA 1

B) MYC

C) RB

D) TP 53

E) RAS

Answer will be posted in the comments section.